ARIA Safety Guardrail

Biologic Monitoring

Clinical status for Leqembi/Donanemab pathway progression based on biomarker and MRI safety criteria.

Biologic Prescription Gate

Prescription Blocked

1 condition must be resolved before Leqembi or Donanemab can be prescribed.

p-Tau 217 Biomarker

Blood panel ordered — result pending 3–5 days

MRI Safety Screen

Last scan: 2025-08-20 (237 days ago)

ARIA Flag

No ARIA indicators detected on most recent MRI

Required Actions

p-Tau 217 biomarker result not yet confirmed

Clinical note: ARIA safety guardrail is enforced both in the UI state machine and server-side at the PRESCRIPTION transition. Changes to this logic require a physician-attributed comment.